Protective role of Zingiber officinale Roscoe on Aceclofenac induced oxidative stress in rat liver

Oxidative stress due to abnormal production of reactive oxygen molecules (ROM) is believed to be involved in the etiology of toxicities of many xenobiotics. In this study protective effect of Zingiber officinale (ZO) against Aceclofenac (ACE) induced oxidative stress in rat liver was evaluated. Twenty four young wistar rats were divided into four groups as follows: control group, ACE (single dose of 10 mg/kg body wt., i.p), ACE plus ZO (250 mg/kg) and ACE plus ZO (500mg/kg). The activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx) and glutathione S-transferase (GST) (p<0.001) as well as the concentration of malondialdehyde, as an indicator of lipid peroxidation, were measured to evaluate oxidative stress in homogenates of the liver. ACE administration increased malondialdehyde levels (p<0.001) and decreased SOD, CAT, GSH, GPx and GST activities. Co-administration of ZO as a dose dependent manner (250 & 500 mg/kg) with ACE injections caused significantly decreased malondialdehyde levels as well as elevates SOD, CAT, GSH, GPx and GST (p<0.05 & p<0.001) activities in liver tissue when compared with ACE alone. It can be concluded that Zingiber officinale may prevent ACE-induced oxidative changes in liver by reducing reactive oxygen species.